A new blue gene: NKPD1 variant increases depression risk

Genetics play a strong role in risk for depression, but the identification of specific genes contributing to the disorder has eluded researchers. "By sequencing all of the DNA that codes for mRNA and ultimately, proteins, Dr. Amin and colleagues found a single gene that may account for as much as 4% of the heritable risk for depression," said Doctor John Krystal, Editor of Biological Psychiatry.
To identify the gene, the researchers assessed data from the Erasmus Rucphen Family study, which was composed of a collection of families and their descendents living in social isolation until the past few decades. In a population like this, genetic isolation leads to an amplification of rarely occurring variants with little other genetic variation, providing a more powerful cohort for the discovery of rare variants. Nearly 2,000 people who had been assessed for depressive symptoms were included in the analysis.
Using whole-exome sequencing to examine portions of DNA containing genetic code to produce proteins, Amin and colleagues found that several variants of NKPD1 were associated with higher depressive symptom scores. The association between depressive symptoms and NKPD1 were also replicated in an independent sample of people from the general population, although the replication sample highlighted different variants within NKPD1.
"The involvement of NKPD1 in the synthesis of sphingolipids and eventually of ceramides is interesting," said Dr. Amin, referring to the predicted role of NKPD1 in the body. Altered sphingolipid levels in blood have been associated with depression and have been proposed as a therapeutic target for major depressive disorder.
"We are the first to show a possible genetic connection in this respect," said Dr. Amin, adding that this implies that such a therapy might be beneficial for patients carrying risk variants in the NKPD1 gene.
As with other psychiatric disorders, depression lacks genetic or biochemical markers to aid diagnosis and treatment of the disorder. According to Dr. Amin, moving depression treatment into the era of precision and personalized medicine will require a transition to objective and unbiased measurements where patients are stratified based on the molecular pathology of the disease. "NKPD1 may be one such molecular mechanism," she said.



for more information visit our product website:Buy Vidalista 40 mg Online 
Location: United States

Comments

Post a Comment

Popular posts from this blog

Disrupted brain pathway, altered stress hormones key to TBI impact differences in men, women

The study, "Sex-dependent effects of mild brain blast injury on neuroendocrine stress response," was funded by the Center for Neuroscience and Regenerative Medicine at USU. The findings will be presented at the upcoming Endocrine Society's annual meeting by lead author Ashley Russell, a Neuroscience PhD candidate in the F. Edward Hebert School of Medicine at USU, and USU research assistant Elizabeth Shupe. Almost every tissue in the body is affected by the interaction between the nervous and endocrine systems. They produce the hormones that regulate sleep, mood and metabolism. USU researchers, in collaboration with colleagues at C olorado State University, sought to better understand why it is that blast brain injuries have a different impact on women and men, specifically in the neuroendocrine system. They conducted hormonal, behavioral and anatomical studies measuring the integrity of the body's major neuroendocrine system, the hypothalamic-pituitary-adrenal (HP...
Read more

Late sleep-wake time preference linked to depression in individuals with diabetes

"These findings are important because depression is common in patients with type 2 diabetes," said lead investigator Sirimon Reutrakul, M.D., an associate professor at Mahidol University Faculty of Medicine, Bangkok, Thailand. "Also, previous studies show that untreated depression is related to worse patient outcomes, including diabetes self-care, blood glucose control and diabetes complications." In the general public, people with a later "chronotype," meaning a preference to go to bed late and wake up late, tend to have more symptoms of depression than do people who go to bed early and wake up early (early chronotype or morning preference), past studies have found. Reutrakul and her co-investigators wanted to study people with type 2 diabetes, who have an increased risk of depression, to learn whether a late r chronotype , or preference for evening activity, was independently associated with greater depression symptoms. Because chronotype may diffe...
Read more

Study reverses thinking on genetic links to stress, depression

In fact, a recent study published in  PLOS One  indicates that only about half of scientific discoveries will be replicated and stand the test of time. So perhaps it shouldn't come as a surprise that new research led by Washington University School of Medicine in St. Louis shows that an influential 2003 study about the interaction of genes, environment and depression may have missed the mark. Since its publication in Science, that original paper has been cited by other researchers more than 4,000 times, and some 100 other studies have been published about links between a serotonin-related gene, stressful life events and depression risk. It indicated that people with a particular variant of the serotonin transporter gene were not as well-equipped to deal with stressful life events and, when encountering significant stress, were more likely to develop depression. Such conclusions were widely accepted, mainly because antidepressant drugs called selective serotonin reuptake...
Read more